Human Recombinant IL12 (from CHO cells)

Supplier: BioVision
AB52086-10 AB52086-100
10006-232EA 399.44 USD
10006-232 10006-234
Human Recombinant IL12 (from CHO cells)
Proteins and Peptides
A T cell-stimulating factor.

The ED₅₀ as determined by the induction of IFN-g production from murine splenocytes co-stimulated with IL-12 is <0.1 ng/ml, corresponding to a specific activity of > 1 x 10⁷ units/mg.

IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-g production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-g producing Th1 cells. Recombinant human IL-12 is a 75 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
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