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Shiga Toxin, List Biological

Supplier: List Biological Laboratories, Inc.
161 162 164
Shiga toxin is a group of related toxins produced by Shigella dysenteriae and enterohemorrhagic Escherichia coli (EHEC)

In the past, these toxins have been differentiated as Shiga, Shiga-like or vero toxins, but since the toxins produced by the two types of bacteria are very similar, distinctions are no longer made. Shiga toxin is produced by specific strains of Escherichia coli in two isoforms, Shiga 1(Stx1) and Shiga 2(Stx2) which share ~60% sequence homology. These Shiga toxins have the same molecular structures, enzymatic activities, receptor specificity and intracellular trafficking process. Shiga toxins are composed of two subunits, an enzymatically active A subunit which is non-covalently attached to the pentameric B subunit, responsible for binding to the target cells. The sugar domain of the glycosphingolipid, globotriaosylceramide, Gb3, located on cell surfaces, is specifically bound by the B-subunit. The toxin is internalized by endocytosis and is transported via a retrograde pathway in the Golgi apparatus to the endoplasmic reticulum. The enzymatic A subunit is then translocated to the cytosol where its N-glycosidase activity irreversibly modifies ribosomal 28S RNA leading to inhibition of protein synthesis and causing cell death. Since the Gb3 receptor is highly expressed in many types of cancers as compared to normal human tissues, the potential use of Shiga toxin to induce apoptosis in cancer cells is currently an active area of research.

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Description Size Supplier No. VWR Catalog Number Unit Price Quantity
Shiga Like Toxin 2 (Verotoxin 2) 10 µg 164 102946-482 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Shiga Toxin 1, Recombinant from Escherichia coli 10 µg 161 102946-478 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Shiga Toxin 2, Recombinant from Escherichia coli 10 µg 162 102946-480 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

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  • State issued document with your organization's Federal Tax ID Number
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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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