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Anthrax Toxins, List Biological

Supplier: List Biological Laboratories, Inc.
172C 172B 171A 172A 173B 176B 177B 176A 178B 177A 9171B 171E 174 171D 172D 175 9172A 9172B 178A 167A 169B 169A 9169A 9169B
Bacillus anthracis is the etiological agent of anthrax

Major virulence factors produced by Bacillus anthracis are the gamma-linked, poly-D-glutamic acid capsule and an exotoxin composed of three components, protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are not toxic separately but act in binary combinations. The complex of PA, the cell binding component, with LF, one of the enzymatic moieties, is termed "lethal toxin" and can cause death. PA and the enzymatic EF together cause skin edema. After secretion, PA is cleaved by membrane peptidases, allowing the 63 kDa carboxy terminal fragment to oligomerize to a heptamer. Cleavage is an essential step in exposing the binding sites for EF and LF. The assembled PA complex and associated LF or EF enters the cell through endocytosis. PA mediates the transfer of LF and EF to the cytoplasm where these enzymes recognize and proteolyze their targets. The LF component, a zinc-dependent metalloprotease, cleaves the mitogen-activated protein kinase kinase (MAPKK), impairing its function and thereby blocking the MAPK signaling pathway. EF is a calmodulin-dependent adenylate cyclase which creates in the cell excess amounts of cyclic-AMP, resulting in edema. Current research is focused on the development of an effective vaccine as well as screening for potent inhibitors of the LF enzymatic activity.




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Description Size Supplier No. VWR Catalog Number Unit Price Quantity
Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis 0.1 mg 178A 102946-442 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis 0.5 mg 173B 102946-428 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Edema Factor (EF-A), Recombinant from Bacillus anthracis 0.1 mg 167A 102946-422 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis 1 mg 176B 102946-436 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis 0.1 mg 176A 102946-434 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis 70 µg 172D 102946-544 Each (70µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis 10 mg 172C 102946-542 Each (10mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis 1 mg 172B 102946-540 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF-A), Recombinant from Bacillus anthracis Native Sequence 1 mg 169B 102946-532 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Lethal Factor (LF-A), Recombinant from Bacillus anthracis Native Sequence 0.1 mg 169A 102946-530 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC) 50 µg 175 102946-432 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis 0.5 mg 174 102946-430 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis 0.5 mg 171E 102946-526 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis 50 µg 171D 102946-524 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis 0.25 mg 177B 102946-440 Each (250µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis 50 µg 177A 102946-438 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

QD Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis 0.1 mg 9172A 102946-546 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

QD Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis 1 mg 9172B 102946-426 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

QD Anthrax Lethal Factor (LF-A), Recombinant from Bacillus anthracis Native Sequence 0.1 mg 9169A 102946-534 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

QD Anthrax Lethal Factor (LF-A), Recombinant from Bacillus anthracis Native Sequence 1 mg 9169B 102946-536 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

QD Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis 1 mg 9171B 102946-528 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Requires a maximum 2 day delivery.

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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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