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C. Difficle Toxins, List Biological

Supplier: List Biological Laboratories, Inc.
152C 154A 155A 157A 158A 159A 155L 153
A major nosocomial pathogen, Clostridium difficile causes antibiotic-associated colitis and intestinal inflammatory disease, together called CDI

By releasing two large protein enterotoxins, Toxin A (TcdA) and Toxin B (TcdB), Clostridium difficile mediates inflammatory diarrhea and compromises intestinal epithelial cells. Either toxin when administered to cultured cells disrupts the cytoskeleton and sets off capsase-dependent apoptosis, although, TcdB is many times more potent than TcdA. Both toxins also activate intestinal epithelial and immune cells to produce cytokines and chemokines, likely contributing to the complications associated with severe CDI. Intracellular targets of TcdA and TcdB are RhoGTPases which regulate many host cell processes including establishing an epithelial barrier and the migration and signaling of immune cells. When the Rho proteins are glycosylated by Toxins A or B, signaling is disrupted leading to the intestinal damage and inflammation characteristic of CDI.




 

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Description Size Supplier No. VWR Catalog Number Unit Price Quantity
Binary Toxin from Clostridium difficile, A Subunit 20 µg 157A 102946-522 Each (20µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Binary Toxin from Clostridium difficile, B Subunit 40 µg 158A 102946-418 Each (40µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Glutamate Dehydrogenase (GDH) from Clostridium difficile, Ships on blue ice overnight 0.1 mg 159A 102946-420 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Toxin A from Clostridium difficile 100 µg 152C 102946-410 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Toxin A Toxoid from Clostridium difficile 100 µg 153 102946-412 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Toxin B from Clostridium difficile 2 µg 155A 102946-416 Each (2µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Toxin B from Clostridium difficile, Liquid, Ships on blue ice overnight 50 µg 155L 102946-520 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Toxin B Toxoid from Clostridium difficile 20 µg 154A 102946-414 Each (20µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
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  • City or County issued Business License
  • State Department of Health Services License
  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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