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Diphtheria Toxin and CRM, List Biological

Supplier: List Biological Laboratories, Inc.
149 150 151
Corynebacterium diphtheriae is a Gram-positive bacterium which infects epithelial cells of the upper respiratory tract and produces diphtheria toxin

Diphtheria toxin is proteolytically cleaved, forming a two part toxin that is held together by a disulfide bridge. The amino-terminal carries the toxin's enzymatic activity, capable of ADP-ribosylation and inactivation of translation elongation factor 2 (EF-2). The carboxy-terminal domain binds to specific host receptors, the heparin-binding EGF-like growth factor (HB-EGF) on human epithelial cells, and translocates the catalytic domain into the cell. After binding to the cell receptor, the toxin is taken up by endocytosis. The pH of the endocytic vesicle then drops and the translocation region of the toxin helps guide the catalytic domain into the host cytoplasm where it is released. Within the cytoplasm, diphtheria toxin catalyzes the ADP-ribosylation of eukaryotic aminoacyl-transferase II (EF-2) using NAD as a substate. This reaction forms the basis for its toxicity toward eukaryotic organisms. Diphtheria toxin is highly potent and as little as one catalytic domain is thought to cause cell death. In cell culture, diphtheria toxin inhibits protein synthesis and causes death in cells carrying the HB-EGF receptor. This toxin has been used to specifically eliminate receptor-expressing cells in transgenic mice.




 

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Description Size Supplier No. VWR Catalog Number Unit Price Quantity
Diphtheria Toxin, unnicked from Corynebacterium diphtheriae 1 mg 150 102946-406 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Diphtheria Toxin CRM197 Mutant from Corynebacterium diptheriae 0.5 mg 149 102946-404 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

Diphtheria Toxoid, from Corynebacterium diphtheriae 0.5 mg 151 102946-408 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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