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Cholera Toxins, List Biological

Supplier: List Biological Laboratories, Inc.
9100B 112 104 105 100B 101C 101B 106 107 102B 103B 15033411
Produced by Vibrio cholerae, cholera toxin (CT) is a multimeric enterotoxin that transfers ADP-ribose to a G protein, locking adenylate cyclase in an 'on' position

By binding to the membrane of enteric cells, cholera toxin stimulates the cellular adenylate cyclase system, causing the hyper-secretion of chloride and bicarbonate ions, which results in increased fluid secretion and the severe diarrhea characteristic of the disease cholera. The pentameric B subunit of CT binds with high efficiency to GM1 monosialoganglioside cell membrane receptors, present in many cell types, allowing its use experimentally in cell culture. Following binding, the toxin is endocytosed and travels retrogradely to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gs protein, which activates adenylate cyclase and as a consequence increasing the intracellular concentration of cAMP. Relevant to the development of vaccine adjuvants, CT effectively modulates mammalian immune systems and acts as an adjuvant for co-administered antigens.




 

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Description Size Supplier No. VWR Catalog Number Unit Price Quantity
Cholera Toxin 1 mg 101B 102946-366 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin 2 mg 101C 102946-368 Each (2mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin (Azide Free) 1 mg 100B 102946-362 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin B Subunit (Choleragenoid) 1 mg 103B 102946-372 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin B Subunit (Choleragenoid) in low salt 0.5 mg 104 102946-374 Each (500µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin B Subunit Biotin 0.2 mg 112 102946-382 Each (200µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC) 0.2 mg 106 102946-378 Each (200µG) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

QD Cholera Toxin (Azide Free), 5 vials min. Purchase Requirement 1 mg 9100B 102946-364 Pack of 5 (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

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  • State issued document with your organization's Federal Tax ID Number
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VWR will not lift restrictions for residential shipping addresses.

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