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H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH, Bachem

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

  • Sequence: H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH
  • CAS-No.: 1176306-10-7
  • Mol.weight: 855.01
  • SumFormula: C₄₀H₆₂N₁₂O₉
  • Bulk item no.: H-7424
  • Synonym(s): Alamandine#(Ala¹)-Angiotensin I/II (1-7)
  • EINECS no.: -
  • MDL no.:

The sequences given for angiotensin I (H-1680) and II (H-1705) correspond to the sequences of human, horse, sheep, pig, mouse, and rat angiotensins I and II.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 mg H-7424.0010 10796-724 Each (10mg) Retrieving
25 mg H-7424.0025 10796-726 Each (25mg) Retrieving
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Protein/Peptide Name Angiotensin A (1-7)
CAS No. 1176306-10-7
Molecular Weight 855.01
Molecular Formula C₄₀H₆₂N₁₂O₉
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Peptide Angiotensin A (1-7)
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