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Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH, Bachem

The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.

  • Sequence: Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • CAS-No.: 161818-04-8
  • Mol.weight: 4125.68
  • SumFormula: C₁₈₇H₂₈₃N₅₁O₅₃S
  • Bulk item no.: H-7422
  • Synonym(s):
  • EINECS no.: -
  • MDL no.:

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-7422.0500 10796-762 Each (500µG) Retrieving
1 mg H-7422.1000 10796-764 Each (1mg) Retrieving
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Protein/Peptide Name (Pyr3)-beta-Amyloid (3-40)
CAS No. 161818-04-8
Molecular Weight 4125.68
Molecular Formula C₁₈₇H₂₈₃N₅₁O₅₃S
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Peptide (Pyr3)-beta-Amyloid (3-40)
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