(Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate, Bachem

Supplier: BACHEM AMERICAS INC
4089804.1000 4089804.0500
10796-832EA 707.71 USD
10796-832 10796-830
(Gln22/Asn23)-Amyloid B-Prot Trifluoroacetate, Bachem
Proteins and Peptides
Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Aβ precursor protein in brain (Tg-SwDI) accumulate abundant cerebral microvascular fibrillar amyloid deposits and exhibit robust neuroinflammation. In vitro, the doubly mutated Aβ peptides showed an increased propensity to fibrillation and pathogenicity compared to the Dutch and Iowa single mutants.
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