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H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH, Bachem

The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His⁶ by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.

  • Sequence: H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • CAS-No.: 1802084-26-9
  • Mol.weight: 4348.91
  • SumFormula: C₁₉₄H₃₀₀N₅₄O₅₈S
  • Bulk item no.: H-7336
  • Synonym(s): Amyloid β-Protein (1-40) English Mutation#Amyloid β-Protein (1-40) H6R
  • EINECS no.:
  • MDL no.:

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-7336.0500 H-7336.0500BA Each (1mg) Retrieving
1 mg H-7336.1000 H-7336.1000BA Each (1mg) Retrieving
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Protein/Peptide Name (Arg6)-beta-Amyloid (1-40)
CAS No. 1802084-26-9
Molecular Weight 4348.91
Molecular Formula C₁₉₄H₃₀₀N₅₄O₅₈S
Storage Conditions -20 ± 5 °C
Salt Trifluoroacetate
Peptide (Arg6)-beta-Amyloid (1-40)
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