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H-Gly-His-Arg-Pro-NH₂, Bachem

The central E region of fibrin contains two sets of polymerization knobs, A and B, that are cryptic in fibrinogen but become exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions are known from X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and double-D are crystallized in the presence of both peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH₂ (GPRP-amide, H-1998) forms H-bond interactions with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a. In the same manner, the knob B peptide mimic H-Gly-His-Arg-Pro-NH₂ (GHRP-amide, H-7318) interacts with residues Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b.

  • Sequence: H-Gly-His-Arg-Pro-NH₂
  • CAS-No.: 209623-54-1
  • Mol.weight: 464.53
  • SumFormula: C₁₉H₃₂N₁₀O₄
  • Bulk item no.: H-7318
  • Synonym(s): GHRP amide
  • EINECS no.: -
  • MDL no.: MFCD20488082

Anticoagulant and antithrombotic peptides. Please see also the product family 'Hirudin Fragments and Analogs', the inhibitors N-1065, N-1215, N-1260, N-1565, and N-1970, and the anticoagulant anisindione, Q-1085.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
25 mg H-7318.0025 H-7318.0025BA Each (25mg) Retrieving
5 mg H-7318.0005 H-7318.0005BA Each (5mg) Retrieving
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Protein/Peptide Name H-Gly-His-Arg-Pro-Nh2
CAS No. 209623-54-1
Molecular Weight 464.53
Molecular Formula C₁₉H₃₂N₁₀O₄
Storage Conditions -20 ± 5 °C
Salt Acetate
Peptide H-Gly-His-Arg-Pro-Nh2
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