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H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val-OH, Bachem

The reactive thioether of Met³⁵ is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.

  • Sequence: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val-OH
  • CAS-No.: 1802086-31-2
  • Mol.weight: 4311.83
  • SumFormula: C₁₉₅H₂₉₇N₅₃O₅₈
  • Bulk item no.: H-7312
  • Synonym(s): (Nle³⁵) β-Amyloid (1-40)
  • EINECS no.:
  • MDL no.:

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg H-7312.0500 H-7312.0500BA Each (500µG) Retrieving
1 mg H-7312.1000 H-7312.1000BA Each (1mg) Retrieving
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Protein/Peptide Name (Nle35)-beta-Amyloid 1-40
CAS No. 1802086-31-2
Molecular Weight 4311.83
Molecular Formula C₁₉₅H₂₉₇N₅₃O₅₈
Storage Conditions -20 ± 5 °C
Salt Ammonium
Peptide (Nle35)-beta-Amyloid 1-40
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