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Anti-FGA Rabbit Polyclonal Antibody

Supplier: Bioss

Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Recommended Dilutions: IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: Bovine Fibrinogen
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Bovine




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg BS-10361R 10365-762 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Fibrinogen
Antigen Symbol FGA
Antigen Synonyms Fib2, Fibrinogen alpha chain, FGA, Fibrinogen A alpha polypeptide chain, Leucine-rich repeats and calponin homology (CH) Domain containing 4
Clonality Polyclonal
Concentration 1 μg/μl
Conjugation Unconjugated
Cross Adsorption No
Form liquid
Gene ID 522039
Host Rabbit
ImmunoChemistry Yes
ImmunoFluorescence Yes
Isotype IgG
Purification Purified by Protein A
Reactivity Bovine
Shipping Temperature 4°C
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage Temperature Store at -20°C for 12 months
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