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Anti-NTRK1 Rabbit Polyclonal Antibody

Supplier: Bioss

The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

Recommended Dilutions: Western Blot: 1:100-1000; Flow Cytometry: 1:20-100; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: NTRK1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg BS-10210R 10364-040 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Neurotrophic Tyrosine Kinase Receptor, Type 1
Antigen Symbol NTRK1
Antigen Synonyms TRKA, Trk-A, TRK, p140-TrkA, kinase TrkA, NTRK1, High affinity nerve growth factor receptor precursor, EC 2.7.10.1, TRK1 transforming tyrosine kinase protein, Slow nerve growth factor receptor
Clonality Polyclonal
Concentration 1 μg/μl
Conjugation Unconjugated
Cross Adsorption No
Flow Cytometry Yes
Form liquid
Gene ID 4914
Host Rabbit
ImmunoChemistry Yes
Isotype IgG
Purification Purified by Protein A
Reactivity Rat, Human, Mouse
Shipping Temperature 4°C
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Western Blot Yes
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