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Anti-AKT1 Rabbit Polyclonal Antibody

Supplier: Bioss

AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: AKT1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg BS-10134R 10362-830 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name V-Akt Murine Thymoma Viral Oncogene Homolog 1
Antigen Symbol AKT1
Antigen Synonyms kinase Akt1, Murine thymoma viral (v-akt) homolog-2, RAC-BETA, RAC-PK-beta, rac protein kinase beta, RAC-gamma, PKBBETA, PKBB, PRKBG, EC 2.7.11.1, Protein kinase B, RAC-beta serine/threonine-protein kinase, C-AKT, RAC, RAC-PK-alpha, STK-2, Protein kinase B beta, Protein kinase Akt-2, AKT2, PRKBB, PKBG, RAC-gamma serine/threonine-protein kinase, v-akt murine thymoma viral oncogene homolo, AKT, RAC-PK-gamma, AKT1 kinase, PKB gamma, PKB-GAMMA, PKB, RAC-gamma serine/threonine protein kinase, PKB-alpha, RAC-alpha serine/threonine kinase, PKB beta
Clonality Polyclonal
Concentration 1 μg/μl
Conjugation Unconjugated
Cross Adsorption No
Form liquid
Gene ID 207
Host Rabbit
ImmunoChemistry Yes
Isotype IgG
Modification Ser473/Tyr474
Purification Purified by Protein A
Reactivity Mouse, Human, Rat
Shipping Temperature 4°C
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Western Blot Yes
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