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Anti-MST1R Rabbit Polyclonal Antibody

Supplier: Bioss
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: MST1R
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg BS-10118R 10362-256 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol MST1R
Antigen Name Macrophage Stimulating 1 Receptor
Reactivity Mouse, Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms soluble RON variant 3, PTK8 protein tyrosine kinase 8, MST1R variant RON30, soluble R, MSP receptor, p185-Ron, RON, soluble RON variant 2, CD136, PTK8, RON variant E2E3, macrophage-stimulating protein receptor, CDw136, c-met-related tyrosine kinase, soluble RON variant 1, MST1R variant RON62
Gene ID 4486
Modification Tyr1238/Tyr1239
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 1235-1245/1400
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Shipping Temperature 4°C
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