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Anti-FEZ1 Rabbit Polyclonal Antibody (Biotin)

Supplier: Bioss
Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: FEZ1
Clonality: Polyclonal
Conjugation: Biotin
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-9721R-BIO 10496-144 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol FEZ1
Antigen Name Fasciculation and Elongation Protein Zeta 1
Reactivity Mouse, Rat, Human
Conjugation Biotin
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms Fasciculation and elongation protein zeta-1, Zygin I, FEZ1
Gene ID 9638
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Shipping Temperature 4°C
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