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Anti-KCNMB1 Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss
BS-7689R-CY5
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: KCNMB1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-7689R-CY5 10467-526 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol KCNMB1
Antigen Name Potassium Large Conductance Calcium-activated Channel Subfamily M Beta member 1
Reactivity Human, Mouse, Rat
Conjugation Cy5®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms slo-beta-1, hbeta1, hslo-beta, BKbeta1, K(VCA)beta, k(VCA)beta-1, SLO-BETA
Gene ID 3779
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at -20°C for 12 months
Shipping Temperature 4°C
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