Anti-STK3+STK4 Rabbit Polyclonal Antibody (Cy7®)

BS-7599R-CY7
10465-498EA 609.78 USD
10465-498
Anti-STK3+STK4 Rabbit Polyclonal Antibody (Cy7®)
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: STK3+STK4
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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