Anti-BNIP3L Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss

BS-5798R-CY5.5
10423-810EA 811.1 USD
10423-810
Anti-BNIP3L Rabbit Polyclonal Antibody (Cy5.5®)
Antibodies
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: BNIP3L
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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