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Anti-PFKL Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

BS-4027R-HRP

10391-792EA 607.67 USD

10391-792

Anti-PFKL Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Phosphofructokinases (PFKs) are regulatory glycolytic enzymes that catalyze the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Mammalian PFK is a tetramer made up of diverse combinations of three isoenzymes: muscle (PFK-1), liver (PFKL) and platelet (PFKP). PFKL (phosphofructokinase, liver), also referred to as PFK-B (Phosphofructo-1-kinase isozyme B), phosphofructokinase 1 or phosphohexokinase, predominates in organs with active gluconeogenesis, such as liver and kidney. Overexpression of PFKL in transgenic mice results in a diminished glucose-induced insulin response, which suggests that PFKL may play a role in glucose-induced insulin secretion. PFKL is expressed at high levels in Down's syndrome (DS) patients, suggesting a possible role for PFKL in the pathogenesis of DS.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: PFKL
Clonality: Polyclonal
Clone:
Conjugation: HRP (Horseradish Peroxidase)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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