Anti-CYP2R1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss

BS-3900R-A488
10389-582EA 811.1 USD
10389-582
Anti-CYP2R1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Antibodies
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor.Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CYP2R1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype:
Reactivity:
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