Anti-KDM3B Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss

10388-332EA 776.17 USD
Anti-KDM3B Rabbit Polyclonal Antibody (Alexa Fluor® 488)
JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: KDM3B
Clonality: Polyclonal
Conjugation: Alexa Fluor® 488
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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