Anti-PS2 Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss

BS-3815R-CY5
10388-206EA 811.1 USD
10388-206
Anti-PS2 Rabbit Polyclonal Antibody (Cy5®)
Antibodies
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PS2
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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