Anti-TP73 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Supplier: Bioss

10386-758EA 776.19 USD
Anti-TP73 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
P73 protein is a structural and functional homologue of p53, a tumor suppressor gene. In this study, The p73 protein, p19ras, by the yeast two-hybrid screening method. Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins. However, unlike other Ras proteins, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus. Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity. In this study, when p19ras was bound to MDM2, it further inhibited the association of MDM2 to the p73 protein. Therefore, this study presents a novel pathway of Ras signaling that occurs in the nucleus, involving p19ras and p73.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: TP73
Clonality: Polyclonal
Conjugation: Alexa Fluor® 647
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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