Anti-TSC2 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss

BS-3586R-CY3
10370-680EA 811.1 USD
10370-680
Anti-TSC2 Rabbit Polyclonal Antibody (Cy3®)
Antibodies
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: TSC2
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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