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Anti-INPP5D Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss

BS-3567R-A488

10374-942EA 746.42 USD

10374-942

Anti-INPP5D Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Antibodies

SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: INPP5D
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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