Anti-PIN1 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss

10375-028EA 776.17 USD
Anti-PIN1 Rabbit Polyclonal Antibody (Cy3®)
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: PIN1
Clonality: Polyclonal
Conjugation: Cy3®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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