Anti-SMAD2 + SMAD3 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Supplier: Bioss

BS-3484R-A350
10369-688EA 811.1 USD
10369-688
Anti-SMAD2 + SMAD3 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antibodies
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SMAD2 + SMAD3
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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