Anti-RCC1 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss

10367-964EA 776.19 USD
Anti-RCC1 Rabbit Polyclonal Antibody (Cy5.5®)
Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin , but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: RCC1
Clonality: Polyclonal
Conjugation: Cy5.5®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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