Anti-LRP6 Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss

BS-3253R-CY7

10366-312EA 776.17 USD

10366-312

Anti-LRP6 Rabbit Polyclonal Antibody (Cy7®)

Antibodies

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Recommended Dilutions: IF(IHC-P): 1:50-200; IF(ICC)(1:50-200

Type: Primary
Antigen: LRP6
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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