Anti-IKK beta Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: Bioss

10366-108EA 776.19 USD
Anti-IKK beta Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: IKK beta
Clonality: Polyclonal
Conjugation: HRP (Horseradish Peroxidase)
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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