Anti-HDAC7 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Supplier: Bioss

BS-3216R-A647

10354-024EA 776.19 USD

10354-024

Anti-HDAC7 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Antibodies

HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: HDAC7
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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