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Anti-IRS1 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: IRS1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3197R-CY3 10353-484 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol IRS1
Antigen Name Insulin Receptor Substrate 1
Reactivity Rat, Human, Mouse
Conjugation Cy3®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms p-IRS1, IRS 1, HIRS 1, Insulin Receptor Substrate 1, HIRS1, IRS-1, IRS1, IRS1Tyr1229
Gene ID 3667
Modification phospho-Ser1101
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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