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Anti-IRF7 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: IRF7
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3196R-A488 10355-802 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol IRF7
Antigen Name Interferon Regulatory Factor 7
Reactivity Rat, Mouse, Human
Conjugation Alexa Fluor® 488
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms IMD39, IRF-7H, IRF7A, IRF7B, IRF7H, IRF7C
Gene ID 3665
Modification phospho-Ser471/Ser472
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 450-490/503
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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