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Anti-H2AFX Rabbit Polyclonal Antibody (Biotin)

Supplier: Bioss
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Recommended Dilutions: IHC-P: 1:100-500

Type: Primary
Antigen: Histone H2A.X
Clonality: Polyclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3185R-BIO 10353-770 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol H2AFX
Antigen Name H2A histone Family, member X
Reactivity Rat, Human, Mouse
Conjugation Biotin
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms gamma-H2AX, H2AFX anitbody, H2A.x, H2A histone family member X, H2AX, histone H2A
Gene ID 3014
Modification phospho-Ser140
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 100-142/143
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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