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Anti-H2AFX Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Supplier: Bioss

BS-3185R-A488

10353-764EA 811.1 USD

10353-764

Anti-H2AFX Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Antibodies

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: Histone H2A.X
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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