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Anti-CDK9 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Supplier: Bioss
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CDK9
Clonality: Polyclonal
Clone: 0
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity:



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3097R-A647 10351-248 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol CDK9
Antigen Name Cyclin-dependent Kinase 9
Reactivity Human, Rat, Mouse
Conjugation Alexa Fluor® 647
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms TAK, C-2k, CTK1, tat-associated kinase complex catalytic subunit, CDC2-related kinase, PITALRE, serine/threonine protein kinase PITALRE, RP11-228B15.5, CDC2L4, Cell Division Cycle 2-like protein kinase 4, cell division protein kinase 9, serine/threonine-protein kinase PITALRE
Gene ID 1025
Modification phospho-Thr186
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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