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Anti-CBL Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CBL
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3090R-CY5.5 10351-168 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol CBL
Antigen Name Cbl proto-oncogene, E3 Ubiquitin Protein Ligase
Reactivity Mouse, Rat, Human
Conjugation Cy5.5®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms RNF57, CBL-3, RING finger protein 57, Signal transduction protein CBL-C, SH3-binding protein CBL-C, CBLC
Gene ID 867
Modification phospho-Tyr774
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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