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Anti-CBL Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss
The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL’s interaction with downstream targets of tyrosine kinases, such as PI 3K and Vav.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CBL
Clonality: Polyclonal
Clone:
Conjugation: Cy7®
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3089R-CY7 10351-154 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol CBL
Antigen Name Cbl proto-oncogene, E3 Ubiquitin Protein Ligase
Reactivity Human, Rat, Mouse
Conjugation Cy7®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms SH3-binding protein CBL-C, RING finger protein 57, RNF57, CBLC, Signal transduction protein CBL-C, CBL-3
Gene ID 867
Modification phospho-Tyr731
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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