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Anti-CTNNB1 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CTNNB1
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype:
Reactivity:



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3084R-CY3 10351-028 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol CTNNB1
Antigen Name Catenin beta
Reactivity Rat, Human, Mouse
Conjugation Cy3®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms CTNNB1, Catenin beta, ORF Names: OK/SW-cl.35, Beta-catenin, Catenin beta-1, PRO2286, CTNNB
Gene ID 1499
Modification phospho-Ser33/37
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 2-52/781
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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