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Anti-ABL1 Rabbit Polyclonal Antibody (Cy5.5®)

Supplier: Bioss
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ABL1
Clonality: Polyclonal
Clone:
Conjugation: Cy5.5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3071R-CY5.5 10350-784 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol ABL1
Antigen Name Abelson Murine Leukemia Viral Oncogene Homolog 1
Reactivity Human, Rat, Mouse
Conjugation Cy5.5®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms c-p150, non-receptor tyrosine kinase, ABL, JTK7, v-abl, ABL proto-oncogene 1, c-ABL, bcr/abl
Gene ID 25
Modification phospho-Tyr89
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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