Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: CENPA
Clonality: Polyclonal
Clone: 0
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: