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Anti-BLNK Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Bioss
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: BLNK
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-3054R-FITC 10350-604 Each (100µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol BLNK
Antigen Name B-cell linker
Reactivity Human
Conjugation FITC (Fluorescein Isothiocyanate)
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms bca, SLP-65, B cell adaptor containing SH2 domain, cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, Src homology [SH2] domain-containing leukocyte protein of 65 kD, BASH, SLP65, B cell linker protein, B-cell adapter containing a Src homology 2 domain protein, B-cell adapter containing a SH2 domain protein, AGM4, BLNK-S, B-cell linker protein, LY57, B-cell activation
Gene ID 29760
Modification phospho-Tyr96
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 70-120/456
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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