Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (Biotin)

BS-2912R-BIO
10348-318EA 545.21 USD
10348-318
Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (Biotin)
A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.

Recommended Dilutions: IHC-P: 1:100-500

Type: Primary
Antigen: MAP1A/MAP1B LC3 A/B
Clonality: Polyclonal
Clone:
Conjugation: Biotin
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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