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Anti-GUCY1A2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Supplier: Bioss
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: Guanylyl Cyclase alpha 2
Clonality: Polyclonal
Conjugation: HRP (Horseradish Peroxidase)
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-13545R-HRP 10300-588 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol GUCY1A2
Antigen Name Guanylyl Cyclase alpha 2
Reactivity Human, Rat, Mouse
Conjugation HRP (Horseradish Peroxidase)
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms GUC1A2, alpha-2 chain, GCS-alpha-2, GUCY1A2, GUCSA2, Guanylate cyclase soluble
Gene ID 2977
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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