Anti-GNS Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Supplier: Bioss

BS-13479R-A350
10299-024EA 811.1 USD
10299-024
Anti-GNS Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Antibodies
GNS is a 552 amino acid lysosomal enzyme that hydrolyzes the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate and heparan sulfate. A member of the sulfatase family, GNS assists in the catabolism of heparin, and binds calcium as a cofactor. GNS deficiency results in an autosomal recessive lysosomal storage disorder known as mucopolysaccharidosis type IIID (Sanfilippo D syndrome), which is characterized by mild somatic disease and severe degeneration of the central nervous system. Subject to post-translational internal peptidase cleavage, GNS is encoded by a gene mapping to human chromosome 12q14.2 and mouse chromosome 10 D2.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: GNS/Glucosamine 6 sulfatase
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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