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Anti-BRCA2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Supplier: Bioss
BS-1210R-A555
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: BRCA2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-1210R-A555 10272-678 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol BRCA2
Antigen Name Breast Cancer type 2 susceptibility protein
Reactivity Human, Mouse, Rat
Conjugation Alexa Fluor® 555
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms breast cancer type 2 susceptibility protein, BRCA1/BRCA2-containing complex, breast and ovarian cancer susceptibility gene, breast cancer susceptibility protein BRCA2, early onset, subunit 2, fanconi anemia group D1 protein, breast cancer 2 tumor suppressor
Gene ID 675
Concentration 1 μg/μl
Cross Adsorption No
Immunogen 1-50/3418
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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