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Anti-SETDB1 Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss
ESET is a nuclear protein belonging to the histone-lysine methyltransferase family and to the Suvar3-9 subfamily. It is a highly conserved protein of 150 amino acids that has been implicated in chromatin structure modulation. ESET is excluded from cell nucleoli and areas of condensed chromatin and can associate with the nonpericentromeric regions of chromatin. The gene encoding for this protein, SETDB1, maps to chromosome 1q21. ESET is a histone methyltransferase, methylating Lys-9 of histone H3 and mutations within the SETDB1 gene abolishes its methyltransferase activity. This methylation acts as a tag for epigenetic transcriptional repression by rounding up HP1 proteins to methylated histones. ESET is widely expressed with highest levels found in testis.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: SETDB1
Clonality: Polyclonal
Conjugation: Cy7®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-11670R-CY7 10261-424 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol SETDB1
Antigen Name SET Domain, Bifurcated 1
Reactivity Human, Mouse, Rat
Conjugation Cy7®
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms MGC90670, Lysine N-methyltransferase 1E, Histone H3 K9 methyltransferase 4, ERG-associated protein with SET domain, mKIAA0067, SETB1_HUMAN, 1, ESET, Histone lysine N methyltransferase, SET domain burcated 1, Histone-lysine N-methyltransferase SETDB1, KMT1E, H3-K9-HMTase 4, SETDB1, H3-K9-HMTase4, SETB, Similar to DNA topoisomerase II., Set domain protein, H3 K9 HMTase 4, Histone H3-K9 methyltransferase 4, KIAA00067, KG1T, KIAA0067, burcated, H3 lysine 9 specic 4
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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