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Anti-MCPH1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Supplier: Bioss
Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80% identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents; this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans; this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: MCPH1
Clonality: Polyclonal
Conjugation: Alexa Fluor® 555
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL BS-11227R-A555 10251-788 Each (100µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol MCPH1
Antigen Name Microcephalin 1
Reactivity Human, Mouse
Conjugation Alexa Fluor® 555
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
ImmunoChemistry Yes
Antigen Synonyms BRCT repeat inhibitor of TERT expression 1, MCPH1_HUMAN, BRIT1, MCT Microcephalin 1, Microcephalin-1, Hypothetical protein FLJ12847, MCPH 1, Microcephaly primary autosomal recessive 1., BRIT 1, FLJ12847, MCPH1
Concentration 1 μg/μl
Cross Adsorption No
Purification Purified by Protein A
Form liquid
Storage Buffer Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage Temperature Store at 4°C for 12 months
Shipping Temperature 4°C
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